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Shanedorf last won the day on August 28 2019

Shanedorf had the most liked content!

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3,070 All-Pro



  • NFL Team
    The Mighty Green Bay Packers
  1. Coronavirus (COVID-19) - 3rd try

    thx for posting that one. From the linked article: "Vir cites four possible uses of the antibodies. First, for prevention of disease. For example, in health care workers at high risk of becoming infected, or for people at high risk of severe disease or death. Second, to prevent progression of the disease in infected patients during the early phases. Third, for treatment of severe disease. And fourth, to develop vaccines." Having an anti-virus antibody is a huge first step, but it has to pass tests on specificity, potency, binding affinity and how long it persists in the blood stream Each of the 4 uses listed above helps and the vaccine is the most potent one of all. If you dose a patient with these anti-SARS Cov2 antibodies, it represents a small army going against a much bigger army because while the virus can replicate and make more - you only have the army you are dosed with. And its hard to give a patient a large enough dose to overcome the viral army without having significant side effects. The vaccine on the other hand teaches your body how to make its own antibodies and then your body can make enough overcome the viral army. Tweaked drugs and drug cocktails have an advantage over antibodies in that they are generally small molecules ( read: simple) that are easier to make and can be dosed as a pill. Whereas an antibody treatment must be dosed IV and that's a bigger challenge with an overloaded healthcare system. There's probably not going to be a one-size- fits- all answer. Its going to be a combination of treatments, preventions etc depending on the situation and the patients. What works at a big- city hospital in Boston may differ from what works in a rural setting or a 3rd world country. We need a full arsenal. The Gates Foundation along with WHO have rolled out the COVID -19 Therapeutic Accelerator and they are coordinating and funding these as a joint effort which leads to the last comment in your post : "One thing that is so invigorating about this pandemic is that we have the totality of our collective brainpower focused solely on collectively crushing SARS-2. that's pretty cool" Yes it is
  2. Stock Investing

    I don't think Norwegian is going to be doing very well in the near future, lying to customers isn't the winning strategy in a crisis. I hope this sinks them for a very long time https://www.newsweek.com/norwegian-cruise-lines-leaked-emails-show-company-urging-employees-lie-about-coronavirus-1491777 "The coronavirus can only survive in cold temperatures, so the Caribbean is a fantastic choice for your next cruise," one part of an email reads. "Scientists and medical professionals have confirmed that the warm weather of the spring will be the end of the Coronavirus." "Mr Becker, due to the coronavirus we have cancelled all of our Asia cruises on the Norwegian Spirit," the email reads. "This has caused a huge surge in demand for all of our other itineraries. I suggest we secure your reservation today to avoid you paying more tomorrow."
  3. What Are You Thinking About v.CC

    Agreed. And one of the issues is that when a company feels like they are spec'd in, they sometimes don't give the full-on service they should be Meanwhile Competitor X is talking to the customer about what they like/don't like and honing in on a way to displace the incumbent No clue on the specifics here - but I've been on both sides of that issue. And sometimes you find out the customer switched because the sister of the CEO works at the competitor - nothing you can do about that
  4. Tyler Ervin back on 1 year deal

    I'm reluctant to invest the draft capital required to find a football player good enough to beat out a 4 yr pro in such a multiple role as Ervin. RB/WR/KR/PR 5th-7th round rookies generally can't do it and 1- 3rd round rookies are too much capital. I think Ervin makes the roster, bubble or no. The new CBA calls for even less coaching/development time than in previous seasons. On top of that - there's little or no offseason, no OTA's and even TC starting on time isn't a given at this point. Ergo, development time is severely restricted and UDFA and late rounders are mostly gonna be redshirts in 2020. I'm thinking vets have a significant advantage over youngsters for this upcoming season.
  5. 2020 NFL Draft Discussion

    I loved the comment from his brother Shannon during his HOF induction speech... " I'm not even the best football player in my family"
  6. Packers sign Devin Funchess

    Packers trade Kumerow for JJ Watt and 4th round pick
  7. The Car Thread

    Mr Clueless checking in, seeking some advice We've got a 2003 Toyota Highlander that the kids drive and its starting to leak oil on a consistent basis. Not a lot, we're talking a silver dollar sized spot under the car each day. I'm reluctant to invest a lot of coin in this ancient car, but I'm wondering if anybody has any thoughts on this and I know its a difficult question to answer given the limited info How much work/ $$ is it for a shop to investigate the source and given the age of the vehicle, is it likely to be the end of the line ? Do we just top off the oil from time to time and live with it ? Any insight appreciated
  8. Packers re-sign Mason Crosby to 3 year deal

    Crosby needs one of these to fulfill his Packer career. Most here weren't even born yet, but this was an epic moment in the Packers- bears rivalry
  9. Coronavirus (COVID-19) - 3rd try

    I wrote a little more info here, hope it helps An antibody is a complex protein molecule produced by B cells in response to invaders, an amazing system honed by millions of years of evolution. The five subclasses of antibodies are: Immunoglobulin A (IgA), which is found in high concentrations in the mucous membranes, particularly those lining the respiratory passages and gastrointestinal tract, as well as in saliva and tears. Immunoglobulin G (IgG), the most abundant type of antibody, is found in all body fluids and protects against bacterial and viral infections. Immunoglobulin M (IgM), which is found mainly in the blood and lymph fluid, is the first antibody to be made by the body to fight a new infection. Immunoglobulin E (IgE), which is associated mainly with allergic reactions (when the immune system overreacts to environmental antigens such as pollen or pet dander). It is found in the lungs, skin, and mucous membranes. Immunoglobulin D (IgD), which exists in small amounts in the blood, is the least understood antibody. The first- responders in a respiratory infection are the secretory IgA antibodies, but there are questions about how efficient they are in forming memory cells that lead to lasting immunity. The IgG and IgM antibodies are found in your bloodstream and are the likely source of the new tests linked earlier. The IgM antibody is less specific, but more prolific - so early on it plays a bigger role in knocking down the infections.Then the IgG takes over and is more specific to the exact viral intruder and forms lasting immunity - so you're ready next time around. (Vaccines typically lean on IgG production) All of this takes some time from initial insult until your body builds up the immunity, so you're looking at about 3 weeks post-infection to have useful amounts of these anti-virus antibodies. Once these antibodies bind to the intruder, it initiates a cascade of events that lead to killing of the virus In many ways, these antibodies are tagging the virus so the killing cells can take em out (without killing you at the same time ) The current test kits which are in short supply look for the presence of viral RNA and indicate if you have virus in you right now. An antibody test only shows that you were exposed to the virus at some point, but offer little insight into your current viral load.
  10. Coronavirus (COVID-19) - 3rd try

    FYI - We're not doing politics in this thread, its been locked twice already and we'd rather keep this one rolling along Thx for understanding
  11. This Aint Packers Talk v69

    A recent study by statisticians reveals that the average human has one breast and one testticle
  12. Coronavirus (COVID-19) - 3rd try

    August 4th, thx for posting that video. Everybody has different POV, from politicians to MDs to public health officials to John Q Public This thing looks different depending on where you are sitting. Nobody has a monopoly on The Truth - she's sharing her truth and I'm grateful she did. The comments she makes shine a light on the anxiety of what she and her colleagues are facing day after day after day They are under immense and relentless stress ( life/death) that few humans can handle for any length of time. My heart goes out to them
  13. 2020 Tight End Titillating Talk

    from Andy Benoit at SI with their assessment of the NFC North teams and needs https://www.si.com/nfl/2020/03/25/nfl-draft-team-needs-nfc-north "...And at tight end, some scouts believe that last year’s third-round pick, Jace Sternberger, has the potential to be a high-quality flex receiving weapon. " more from packers.com https://www.packers.com/news/versatility-adds-to-jace-sternberger-s-long-term-upside "His ability to adapt and thrive spoke volumes to both LaFleur and General Manager Brian Gutekunst. "The flexibility he gives us, obviously he's got a lot of speed that can stretch the seam," Gutekunst said during his season-ending news conference last week. "He's a matchup problem for linebackers and safeties. At the end there, you saw Matt put him in the backfield and move him around a little bit. I think that's what you're going to see with Jace. I think he can be one of those guys as he develops where he can play from a lot of different places." “Here’s what I love about Jace Sternberger: I know the game’s not too big for him,” LaFleur said. “He loves to compete, and he’s so versatile. Whether it’s inline, or it’s moving into an H-back, fullback-type position. The guy has contact courage. He’s not afraid to put his face on people. He’s a much better blocker than anyone ever thought he was coming out of Texas A&M. I’m just excited for his future.”
  14. Question: Why do you think Clowney is unsigned?

    "Timothy Hewett, director of research for Ohio State University Sports Medicine and director of the school's Sports Health & Performance Institute, stressed that he knew no specifics of Clowney's case and that microfracture surgery "may very well be" appropriate. "It appears to do well mainly in small lesions (holes) and over the shorter term. I could not say how large his lesion is," said Hewett, who also acknowledged there are doubts about the procedure. "Microfracture is sort of losing favor these days in large part.… It's more of a short-term remedy," said Hewett. "But if you look at the longer-term outcomes after microfracture, they're not very good." Note: that's an old quote from before the microfracture surgery in 2014
  15. 2020 Off-season Discussion Thread

    That might free up ILB Avery Williamson via trade per the comments from J-E-T-S fans https://www.pro-football-reference.com/players/W/WillAv00.htm https://overthecap.com/player/avery-williamson/3090/