ramssuperbowl99 Posted March 2, 2020 Share Posted March 2, 2020 1 minute ago, ET80 said: Legit LOL. I can't remember which special it was on, but it wasn't the one with the gun control bit. Watch it, it's way way meaner because the crowd takes a second or two to figure it out. 1 Link to comment Share on other sites More sharing options...
Shanedorf Posted March 2, 2020 Share Posted March 2, 2020 35 minutes ago, ET80 said: My initial focus was over the sketchy practice of these field sales reps and some of the backdoors taken to get Blockbusters through FDA approvals. (Vioxx was the big story back then, so it was low hanging fruit). The Vioxx story has many facets, one of them was that the entire pharma industry went to a standardized format for submissions to the FDA. Up until that point, companies used different forms, different formats and different ways of sorting the data; each submission was an island unto itself And that prevented the FDA from catching the Vioxx, Celebrex heart issues sooner. Now they all got religion in terms of eCTD ( electronic Common Technical Document) and CDISC (Clinical Data Interchange Standards Consortium) The sales reps are still sketchy as hell but at least there are more eyes watching them now 1 Link to comment Share on other sites More sharing options...
ET80 Posted March 2, 2020 Share Posted March 2, 2020 25 minutes ago, Shanedorf said: The sales reps are still sketchy as hell but at least there are more eyes watching them now This is promising, that was a huge drop on the FDA, I think. One item I was diving into that lent itself to that FDA drop - Blockbusters such as Celebrex and Vioxx, drugs designed to treat symptoms and not necessarily "cure" anything. It's good enough to get you to forget what's wrong for 4-6 hours, until you need to pop another. These Blockbusters were the holy grail, they created a psuedo dependency, while not really correcting a single thing - when you create a Blockbuster, it's found money in essence. You race to the finish line, and start cashing checks once you get approval and in a pharmacy. In 1987, Merck gave away a vaccine for river blindness to impoverished countries - no earnings, no revenue. From this to pushing a dangerous product such as Vioxx; That's more than an "earnings statement" driven decision, there is something that fundamentally changed in the corporate culture (or at least that's what I was driving towards...) Link to comment Share on other sites More sharing options...
AFlaccoSeagulls Posted March 2, 2020 Share Posted March 2, 2020 1 hour ago, ramssuperbowl99 said: I can't remember which special it was on, but it wasn't the one with the gun control bit. Watch it, it's way way meaner because the crowd takes a second or two to figure it out. Yeah that bit came from his special after the gun control special. He went HAM in that one. So good. Link to comment Share on other sites More sharing options...
Heimdallr Posted March 2, 2020 Share Posted March 2, 2020 spent $34 at the grocery store, $189 at the liquor store. why does this always happen? 1 Link to comment Share on other sites More sharing options...
Dome Posted March 2, 2020 Share Posted March 2, 2020 3 minutes ago, Heimdallr said: spent $34 at the grocery store, $189 at the liquor store. why does this always happen? Because the grocery store doesn’t sell liquor 4 Link to comment Share on other sites More sharing options...
Duluther Posted March 3, 2020 Share Posted March 3, 2020 Wife just put my Camaro of ten years up for sale. Without asking me. Link to comment Share on other sites More sharing options...
Popular Post Webmaster Posted March 3, 2020 Popular Post Share Posted March 3, 2020 4 minutes ago, Duluther said: Wife just put my Camaro of ten years up for sale. Without asking me. Delete Facebook, hit the gym, lawyer up. No one messes with a bitchin camero. 20 Link to comment Share on other sites More sharing options...
Daboyle Posted March 3, 2020 Share Posted March 3, 2020 (edited) 4 minutes ago, Webmaster said: Delete Facebook, hit the gym, lawyer up. No one messes with a bitchin camero. Kings supporting kings You love to see it Edited March 3, 2020 by daboyle250 Link to comment Share on other sites More sharing options...
skywindO2 Posted March 3, 2020 Share Posted March 3, 2020 Looks like bitchin is back on the menu boys 2 Link to comment Share on other sites More sharing options...
ET80 Posted March 3, 2020 Share Posted March 3, 2020 1 hour ago, Webmaster said: Delete Facebook, hit the gym, lawyer up. No one messes with a bitchin camero. Wrong account, @fretgod99. 3 Link to comment Share on other sites More sharing options...
N4L Posted March 3, 2020 Share Posted March 3, 2020 1 hour ago, Webmaster said: Delete Facebook, hit the gym, lawyer up. No one messes with a bitchin camero. Im trying to decide if this is ok to put in my sig 2 Link to comment Share on other sites More sharing options...
Ty21 Posted March 3, 2020 Share Posted March 3, 2020 1 hour ago, N4L said: Im trying to decide if this is ok to put in my sig What’s gonna happen? Webmaster gonna discipline Webmaster? Link to comment Share on other sites More sharing options...
Ty21 Posted March 3, 2020 Share Posted March 3, 2020 @Malfatron I love your avy more than anything on the planet 1 Link to comment Share on other sites More sharing options...
Shanedorf Posted March 3, 2020 Share Posted March 3, 2020 true or false from your point of view ? "The voice in your head has a pre- determined volume, you can not increase or decrease it." "I would be totally fine with mosquitos drinking my blood if the bites didn’t itch afterword." "Flipping a coin and realizing how much you dislike the outcome is more useful for decision making than the actual result of the flip." "I wish it was possible to see your life stats. Like how many bugs you’ve killed, how many chips you’ve eaten, how many miles you’ve driven etc." Link to comment Share on other sites More sharing options...
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