Hunter2_1 Posted April 17, 2020 Share Posted April 17, 2020 19 hours ago, acowboys62 said: I would happily shelter the dogs but not the people, they can freeze. Haha, there are millions (inhale) AND millions who would agree with you, dude 1 Link to comment Share on other sites More sharing options...
mission27 Posted April 17, 2020 Share Posted April 17, 2020 16 minutes ago, mistakey said: i told you did you listen to me? did you?!?! lol @ mbtl pretending he was the first on this train MoL sunk most of their net worth into Gilead in early February Link to comment Share on other sites More sharing options...
ramssuperbowl99 Posted April 17, 2020 Share Posted April 17, 2020 (edited) 20 minutes ago, mistakey said: i told you did you listen to me? did you?!?! March 18th? Bittie please the smart money was on it earlier: EDIT: And here's @ET80's reply confirming that he's a snake in the grass who owes me money Edited April 17, 2020 by ramssuperbowl99 1 Link to comment Share on other sites More sharing options...
mission27 Posted April 17, 2020 Share Posted April 17, 2020 12 minutes ago, ramssuperbowl99 said: March 18th? Bittie please the smart money was on it earlier: EDIT: And here's @ET80's reply confirming that he's a snake in the grass who owes me money It was already at $70 tho You needed to buy at 60-65 earlier this year to get full gains tbh Link to comment Share on other sites More sharing options...
WizeGuy Posted April 17, 2020 Share Posted April 17, 2020 37 minutes ago, Shanedorf said: Remdesivir is a small molecule which means its not that expensive to make compared to a biologic like a vaccine or antibody treatment. However, it has to be dosed IV so its not a candidate for mass delivery to patients unless intravenous- dosing- at home becomes a thing. ( it won't ) And here's a couple of interesting snippets from the Gilead website: Researchers doubt this recent study data is anything more than suggestive, if that. “The data from this paper are almost uninterpretable,” Stephen Evans, a professor of pharmacoepidemiology at the London School of Hygiene & Tropical Medicine, told Bloomberg. “There is some evidence suggesting efficacy, but we simply do not know what would have happened to these patients had they not been given the drug.” Which is why more organized clinical trials with controls are necessary. And Gilead is not denying that. “In studying remdesivir, the question is not just whether it is safe and effective against COVID-19, but in which patients it shows activity, how long should they receive treatment and at what stage of their disease would treatment be most beneficial,” said Daniel O’Day, Gilead’s chairman and chief executive officer. “Many answers are needed, which is why we need multiple types of studies involving many types of patients.” ...about 25% of patients receiving it have severe side effects, including multiple-organ dysfunction syndrome, septic shock, acute kidney injury and low blood pressure. Another 23% demonstrated evidence of liver damage on lab tests." Acute Kidney Injury ( AKI) is a serious problem and one of the biggest killers in the world, leading to more deaths than cancer or heart disease. The other adverse events listed are no picnic either. I don't particularly enjoy being the Grim Reaper every time there is some positive news, but clinical drug development is mostly failure. Its a really tough business to be in and shines a light on how little we actually know. I wonder how much of the side effects are due to the patient already being severely ill. At that stage, wouldn't we assume the bodies immune system is probably weak due to the virus taking a heavey toll? We see a lot of organ failures at this stage of the fight, no? Is it fair to assume it's hard to judge whether it's the drug or the severity of the illness in the patient that is causing complications? I agree with everything you said, though. There are still a lot of unknowns. Safe to say even if this is a viable option it'd only be given to inpatient candidates? So much to learn! Link to comment Share on other sites More sharing options...
mistakey Posted April 17, 2020 Share Posted April 17, 2020 25 minutes ago, mission27 said: lol @ mbtl pretending he was the first on this train MoL sunk most of their net worth into Gilead in early February so what, like 5 bucks? 1 Link to comment Share on other sites More sharing options...
mission27 Posted April 17, 2020 Share Posted April 17, 2020 13 minutes ago, WizeGuy said: I wonder how much of the side effects are due to the patient already being severely ill. At that stage, wouldn't we assume the bodies immune system is probably weak due to the virus taking a heavey toll? We see a lot of organ failures at this stage of the fight, no? Is it fair to assume it's hard to judge whether it's the drug or the severity of the illness in the patient that is causing complications? I agree with everything you said, though. There are still a lot of unknowns. Safe to say even if this is a viable option it'd only be given to inpatient candidates? So much to learn! I don’t think it’s realistic to use as a mass produced prophylactic But it could significantly reduce fatality rates and complications for seriously ill patients if the research is confirmed further which would make this actually like a seasonal flu once our capacity is up 1 Link to comment Share on other sites More sharing options...
Blahstoise Posted April 17, 2020 Share Posted April 17, 2020 https://www.medrxiv.org/content/10.1101/2020.04.14.20062463v1 50-85x the number of confirmed cases in Santa Clara study have antibodies 1 Link to comment Share on other sites More sharing options...
mission27 Posted April 17, 2020 Share Posted April 17, 2020 19 minutes ago, mistakey said: so what, like 5 bucks? plus a bunch of zeros Link to comment Share on other sites More sharing options...
Shanedorf Posted April 17, 2020 Share Posted April 17, 2020 54 minutes ago, WizeGuy said: I wonder how much of the side effects are due to the patient already being severely ill. At that stage, wouldn't we assume the bodies immune system is probably weak due to the virus taking a heavy toll? We see a lot of organ failures at this stage of the fight, no? Is it fair to assume it's hard to judge whether it's the drug or the severity of the illness in the patient that is causing complications? I agree with everything you said, though. There are still a lot of unknowns. Safe to say even if this is a viable option it'd only be given to inpatient candidates? So much to learn! I don't know the answers to your questions, but having a control group is helpful and there wasn't one for the compassionate use study cited above When you see adverse events reported across a large number of patients, its often related to the drug being dosed. Severely ill patients don't metabolize the drug as fast as healthy patients- leading to higher concentration which can lead to more adverse events. Many of these patients had other issues before they were treated and we're seeing diabetics struggle a lot with COVID19 and even non-diabetics having huge swings in blood sugar which messes with all your organs, but especially your kidneys. This doesn't mean remdesivir isn't useful, it means its useful for a smaller subset of patients and that's fairly typical. Every drug has sub-populations where it works and others where it doesn't... and the trials are designed to figure that out. 1 Link to comment Share on other sites More sharing options...
Xenos Posted April 17, 2020 Share Posted April 17, 2020 On April 15, 2020 at 10:38 PM, naptownskinsfan said: And now a Maryland group is doing a copycat gridlock event that Michigan did this Saturday at noon- gridlock the state capital. Does Maryland know that doing a gridlock similar to Michigan is harmful and dangerous? There's better ways to protest without blocking services like buses or hospitals. 1 Link to comment Share on other sites More sharing options...
mistakey Posted April 17, 2020 Share Posted April 17, 2020 59 minutes ago, mission27 said: plus a bunch of zeros 5.0000000 is still 5 bucks 1 Link to comment Share on other sites More sharing options...
mistakey Posted April 17, 2020 Share Posted April 17, 2020 11 minutes ago, Xenos said: Does Maryland know that doing a gridlock similar to Michigan is harmful and dangerous? There's better ways to protest without blocking services like buses or hospitals. I dont mind the protesting - just do it in person you cowards. Kinda give the game away when you wont get out of your car Link to comment Share on other sites More sharing options...
Xenos Posted April 17, 2020 Share Posted April 17, 2020 2 minutes ago, mistakey said: I dont mind the protesting - just do it in person you cowards. Kinda give the game away when you wont get out of your car It's better that they stay in cars actually. Better social distancing. Just don't block vital services that other people need. And you don't need to bring guns and body armor to a protest rally. 2 Link to comment Share on other sites More sharing options...
mission27 Posted April 17, 2020 Share Posted April 17, 2020 15 minutes ago, mistakey said: 5.0000000 is still 5 bucks not in europe tbh 1 Link to comment Share on other sites More sharing options...
Recommended Posts